EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE WITH A VERY HIGHDEGREE OF SULFATION

摘要

A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulatio n parameters and useful in the cosmetic or pharmaceutical field. Also describe d are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.