| 摘要 |
The present invention is concerned with fluorobenzamide derivatives of the general formula, wherein R1 is hydrogen, (C1-C6)-alkyl or hydroxy-(C1-C6)- alkyl; R2 is (C1-C6)-alkyl, -CO-NR8R9, -(CH2)n-NR8R9, -(CH2)P-OR8, or -(CH2) n- CN; R3 is selected from hydrogen, halogen, halogen-(C1-C6)-alkyl, cyano, C1 - C6-alkoxy or halogen-(C1-C6)-alkoxy; R4, R5, R6 and R7 are hydrogen or fluor o, and at least one of R4, R5, R6 and R7 is fluoro; R8 and R9 independently fro m each other are hydrogen or (C1-C6)-alkyl; m is 1, 2 or 3; n is 0, 1, 2 or 3; and p is 1 or 2; as well as their pharmaceutically acceptable salts. The compounds of general formula (I) are selective monoamine oxidase B inhibitor s and therefore they are suitable for the treatment of Alzheimer's disease or senile dementia.
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