| 摘要 |
<p>A glucose dehydrogenase using pyrroloquinoline quinone as a coenzyme, wherein the amino acid residues corresponding to the 349th to 377th residues of water-soluble PQQGDH derived from Acinetobacter calcoaceticus are replaced by other amino acid residues and whose inhibition constant (Ksi) is 200 mM or higher. The thus altered water-soluble PQQGDH is useful in the measuring of glucose in the presence of high-concentration glucose because of low level of substrate inhibition by glucose.</p> |
