OLIGOMERIC COMPOUNDS THAT INCLUDE CARBOCYCLIC NUCLEOSIDES AND THEIR USE IN GENE MODULATION
摘要
Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one carbocyclic nucleoside. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligonucleotide is a carbocyclic nucleoside.
申请公布号
WO03106477(A1)
申请公布日期
2003.12.24
申请号
WO2003US19043
申请日期
2003.06.17
申请人
ISIS PHARMACEUTICALS, INC.;BHAT, BALKRISHEN;DANDE, PRASAD;BHAT, NEELIMA;ELDRUP, ANNE, B.
发明人
BHAT, BALKRISHEN;DANDE, PRASAD;BHAT, NEELIMA;ELDRUP, ANNE, B.