摘要 |
<p>The present invention relates to a process of producing Ala-Gln dipeptide, comprising of: the amino acid protected at N-end reacts with triphenyl phosphine and hexachloroethane in an organic solvent, forming an active ester; the active ester reacts with glutamine in an organic solvent and an aqueous inorganic base solution, acidizing the result reaction mixture with an inorganic acid, deprotected the protection group at N-end. The raw materials are inexpensive. The synthesis process is not difficult. It is not necessary to separate the intermediate, or to purify it. It is easy to separate and purify the product. The reagents used in the process are less toxicity so that it is suit for environment.</p> |