SUBSTITUTED AZABICYCLIC MOIETIES FOR THE TREATMENT OF DISEASE (NICOTINIC ACETHYLCHOLINE RECEPTOR AGONISTS)

摘要

The invention provides compounds of Formula (I): (F) Formula (I) wherein m<1> is 0 or 1; m<2> is 1 or 2; R1 is-H, alkyl, halogenated alkyl, substituted alkyl, cycloakyl, or phenyl; R2 is -H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl, provided that when m<1> is 1 at least one of R1 and R2 is -H; or a pharmaceutically acceptable salt, pharmaceutical composition, a pure enantiomer or racemic mixture thereof. The invention also provides a method for treating a disease or condition in a mammal, wherein the PROPORTIONAL 7 nicotinic acetylcholine receptor is implicated and for treating diseases where there is a sensory-gating deficit in a mammal comprising administering to a mammal a therapeutically effective amount of a compound of Formula (I). These compounds may be in the form of phamaceutical salts or compositions, and may be in pure enantiomeric form or may be racemic mixtures.