发明名称 |
TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX |
摘要 |
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligan d binding domain; a transactivation domain; and a ligand is contacted with a D NA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of t he DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a cla ss of 4-tetrahydorquinolines.
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申请公布号 |
CA2488407(A1) |
申请公布日期 |
2003.12.24 |
申请号 |
CA20032488407 |
申请日期 |
2003.06.13 |
申请人 |
RHEOGENE, INC. |
发明人 |
TICE, COLIN M.;MICHELOTTI, ENRIQUE L.;PALLI, SUBBA REDDY;DHADIALLA, TARLOCHAN S.;THOMPSON, CHRISTINE S. |
分类号 |
A61K31/47;C07D215/42;C07D401/06;C07D405/06;C07D409/06;C07D409/12;C07D413/06;(IPC1-7):C07D413/06;C12P21/00;C07D409/14;C07D215/38;C07D215/44;A61K31/470;C12N15/63 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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