DEOXYHYPUSINE-SYNTHASE INHIBITORS, PHARMACEUTICALS COMPRISING SAID INHIBITORS AND USES THEREOF

摘要

The present invention relates to compounds that are capable of inhibiting the enzyme deoxyhypusine-synthase as well as pharmaceutical compositions that comprise one or more of these compounds, methods for preventing or treating diseases that are affected by inhibiting the activity of the enzyme deoxyhypusine-synthase and/or hypusination of the eukaryotic initiation factor 5A (eIF-5A) and the use of these compounds for the preparation of such a medicament. More particularly, the present invention relates to classes of 1,3-Diazacyclohexanes and 1,3-Diazacyclo-1-hexenes that inhibit the activity of the enzyme deoxyhypusine-synthase and/or hypusination of the eukaryotic initiation factor 5A.