| 摘要 |
1,181,673. Antisecretory medicines. BOOTS PURE DRUG CO. Ltd. 23 Aug., 1967 [2 Sept., 1966; 5 April, 1967], Nos. 39384/66 and 15692/67. Heading A5B. [Also in Divisions C2 and C3] Therapeutic compositions, suitable for oral, rectal or parenteral administration and having antisecretory activity, comprise as an active ingredient novel substituted xanthenes or thiaxanthenes of the formula: wherein R is N(R 1 )-C=X 2 -N(R 2 )R 3 ; X 1 is oxygen or sulphur; X 2 is oxygen or sulphur; R 1 is alkyl, alkenyl, cycloalkyl, substituted alkyl, hydroxy, acyloxy, alkoxy, trialkylsiloxy, or when R 2 is hydroxy or acyloxy, hydrogen; R 2 is hydrogen, alkyl, alkenyl, cycloalkyl, substituted alkyl, trialkysilyl, hydroxy, alkoxy, trialkylsiloxy, or acyloxy; R 3 is hydrogen, alkyl, alkenyl, cycloalkyl, substituted alkyl or acyl; or N(R 2 )R 3 is a 5-7 membered heterocyclic ring; the rings A and B may optionally contain as substituents halogen, alkyl, alkoxy or hydroxy; or (a) esters and amides of these compounds containing a carboxyl group or (b) salts of those compounds containing a carboxyl group or a basic nitrogen atom. The above compositions may if desired be associated with other compatible pharmacologically active ingredients such as, antacids, acid absorbents, sedatives, antihistaminic and/ or antiometic agents and antichcholinegic agents.
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