发明名称 Method of reducing staining of stannous in dentifrice compositions
摘要 Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice. The single phase dentifrice will comprise an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and an effective amount of a stannous anion. The single phase dentifrice has a total water content of up to about 20%, the stannous ion is not delivered from stannous fluoride, a molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1, and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate.
申请公布号 US6667027(B2) 申请公布日期 2003.12.23
申请号 US20010039620 申请日期 2001.10.24
申请人 THE PROCTER & GAMBLE COMPANY 发明人 GLANDORF WILLIAM MICHAEL;BACCA LORI ANN
分类号 A61K8/21;A61K8/24;A61Q11/00;(IPC1-7):A61K7/16;A61K7/18 主分类号 A61K8/21
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