Diagnostics and therapeutics for glaucoma.

摘要

This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).