发明名称 |
BIOMOLECULE OPEN CHANNEL SOLID PHASE EXTRACTION SYSTEMS AND METHODS |
摘要 |
An open capillary channel device for open tubular solid phase extraction of molecules capable of providing a tube enrichment factor of at least 1. The device comprises a channel having one end connected to a pump for pumping liquid and gas, and the other end can be connected to an interface for a protein chip sample applicator or a mass spectrometer, the inner surface of the channel being an extraction surface. The extraction surface can be bonded to an affinity binding agent. The affinity agent can be a chelated metal, a protein, a sugar or nucleic acid with a binding affinity for a selected analyte. The method using this device comprises binding sample molecules from a sample solution to the affinity extraction surface of the capillary channel; and desorbing a substantial portion of the sample molecules from the extraction surface with a desorbent liquid, with an extraction factor greater than 1. |
申请公布号 |
AU2003233498(A1) |
申请公布日期 |
2003.12.22 |
申请号 |
AU20030233498 |
申请日期 |
2003.05.08 |
申请人 |
PHYNEXUS, INC. |
发明人 |
DOUGLAS, T. GJERDE;CHRISTOPHER, P. HANNA |
分类号 |
B01D15/08;B01J20/281;G01N1/34;G01N1/40;G01N30/00;G01N30/06;G01N30/08;G01N30/88;(IPC1-7):G01N33/68 |
主分类号 |
B01D15/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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