发明名称 |
METHOD FOR IDENTIFYING AGONISTS OR ANTAGONISTS FOR THE G-PROTEIN COUPLED MAS-LIKE 1 RECEPTOR |
摘要 |
Identifying a compound (I) that binds specifically to the G protein-coupled receptor mas-like-1 (R) by (i) treating at least one cell that expresses R on its surface (or a preparation of the cells that contains R) with at least one test compound and (ii) detecting any binding to R. Independent claims are also included for the following: (1) similar methods for identifying compounds that bind specifically to R and are competitive with respect to a first compound, or that bind specifically to R and either activate or inhibit it; (2) pharmaceutical composition containing compounds identified by the new methods; (3) use of substance P (or its cleavage products) or neuropeptide FF (a) for treating diseases associated with defects in R or (b) for preparing a complex with R; and (4) protein that comprises R to which substance P (or its cleavage products) or neuropeptide FF is bound specifically. |
申请公布号 |
AU2003237702(A1) |
申请公布日期 |
2003.12.22 |
申请号 |
AU20030237702 |
申请日期 |
2003.05.28 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
JOHANN GASSENHUBER;EVI KOSTENIS |
分类号 |
A61K38/17;A61K38/22;A61K45/00;A61P9/00;C07K14/47;C07K14/705;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/567;G01N33/74;(IPC1-7):G01N33/74;G01N33/566 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|