| 摘要 |
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to erythropoietin liposomal dispersion. Liposome-base composition contains: (a) effective amount of erythropoietin; (b) lipid phase comprising: (i) lecithin or hydrogenated lecithin; (ii) optionally charged electropositive or electronegative lipid compound; and (iii) cholesterol or its derivative taken among cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols) and organic acid derivatives of cholesterols; and (c) phosphate buffer. Invention provides preparing the liposome-base composition for parenteral administration that excludes using human serum albumin and composition shows the excellent stability. EFFECT: valuable medicinal and pharmaceutical properties of dispersion. 14 cl, 2 tbl
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