| 摘要 |
A method for in vitro culture of hepatitis C virus (HCV) comprises contacting particles (A), containing the RNA of HCV, with cells that can synthesize and secrete lipoproteins (LP), in a culture medium that promotes synthesis and secretion of LP, then harvesting the virus produced, is new. Independent claims are also included for: (1) a method of screening and/or selecting antiviral agents (I) by adding test compounds to the medium during the new in vitro culture method; and (2) therapeutic composition that can affect, qualitatively or quantitatively, propagation or replication of HCV in vivo, containing an agent (Ia) able to modulate, repress or inhibit synthesis of LP.
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