发明名称 |
New N-((N,N-disubstituted carbamoyl)-alkyl)-arylsulfonamides, are bradykinin B1 receptor antagonists useful e.g. for treating inflammatory diseases or especially pain |
摘要 |
N-((N-(4-Amidinobenzyl)-N-methylcarbamoyl)-alkyl)-arylsulfonamides (I) are new. Aryl sulfonamide derivatives of formula (I) and their acid addition salts are new. R1 = aromatic nucleus (optionally substituted by one or more of halo, 1-3C alkyl, 1-3C alkoxy, NO2, CN, CF3 or OCF3); R2 = H or 1-4C alkyl (optionally substituted by phenyl, CONH2 or one or more F); R3 = H or OH; R4 = H; or R3 + R4 = -CH=N- or 2-4C alkylene; R5 = H or 1-3C alkyl; R6 = H or halo; Y = optionally unsaturated 2-4C alkylene (optionally interrupted by O). An Independent claim is included for the preparation of (I).
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申请公布号 |
FR2840897(A1) |
申请公布日期 |
2003.12.19 |
申请号 |
FR20020007387 |
申请日期 |
2002.06.14 |
申请人 |
LABORATOIRES FOURNIER S.A. |
发明人 |
BARTH MARTINE;BONDOUX MICHEL;DODEY PIERRE;MASSARDIER CHRISTINE;LUCCARINI JEAN MICHEL |
分类号 |
A61K31/18;A61K31/4164;A61K31/4178;A61K31/551;A61P3/06;A61P9/10;A61P9/12;A61P25/04;A61P25/22;A61P25/24;A61P29/00;A61P37/08;C07C311/19;C07D233/24;C07D233/54;C07D233/64;C07D239/06;C07D243/04;C07D249/08;C07D409/12;(IPC1-7):C07D233/64;A61K31/63;A61K31/416;C07C311/18;C07C311/29 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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