METHOD OF ENHANCING IMMUNOGENICITY BY COVALENT LINKAGE OF ANTIGENS TO PROTEINS ON THE SURFACE OF DENDRITIC CELLS
摘要
A method is provided to increase the immunogenicity of an antigen. This method involves the covalent coupling of the antigen to proteins or glycoproteins present on the surface of dendritic cells by a mild biochemical modification which minimizes the denaturation of the antigen and preserving cell viability. Dendritic cells with covalently linked antigen on their surface can be used for generating a specific response to the antigen. The present method can be used for both therapeutic and preventive purposes.
申请公布号
WO03051907(A3)
申请公布日期
2003.12.18
申请号
WO2002US41460
申请日期
2002.12.18
申请人
HEALTH RESEARCH, INC.;BANKERT, RICHARD, B.;CONWAY, THOMAS, F.;EGILMEZ, NEJAT