| 摘要 |
<p>A method for selecting or designing a compound for modulating the activity of phosphoinositide dependent protein kinase 1 (PDKI), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the protein kinase catalytic domain of PDKI, wherein a three-dimensional structure or at least a part of the protein kinase catalytic domain of PDK1 is compared with a three-dimensional structure of a compound, and a compound that is predicted to interact with the said protein kinase catalytic domain is selected, wherein the three-dimensional structure of at least a part of the protein kinase catalytic domain of PDKI is a three-dimensional structure (or part thereof) determined for a polypeptide consisting of residues equivalent to residues 51 to 359 of full length human PKD1, or fragment or fusion thereof.</p> |
