发明名称 |
METHODS FOR USING ADAMTS-12, AN INTEGRIN AND METALLOPROTEASEWITH THROMBOSPONDIN MOTIFS |
摘要 |
The present invention relates to methods for using a human A Disintegrin And Metalloprotease containing ThromboSpondin repeats (ADAM-TS). The invention also relates to methods for using polynucleotides encoding the metalloprotease. The invention relates to methods using the ADAM-TS polypeptides and polynucleotides as a target for diagnosis and treatment in metalloprotease-mediated or -related disorders. The invention further relate s to drug-screening method using the ADAM-TS polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADAM-TS polypeptid es and polynucleotides. The invention further relates to antagonists identified by drug screening methods with the ADAM-TS polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from a ADAM-TS associated disorder.
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申请公布号 |
CA2493890(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
CA20032493890 |
申请日期 |
2003.06.06 |
申请人 |
ATHERSYS, INC. |
发明人 |
FABER, PIETER W.;TING, ANTHONY EUGENE;JACKSON, PAUL DAVID |
分类号 |
G01N33/53;A61B;A61K38/00;A61K39/395;A61K45/00;A61P9/00;A61P9/10;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C07H21/04;C12N9/64;C12N15/00;C12N15/09;C12Q1/00;C12Q1/02;C12Q1/37;C12Q1/68;G01N33/50;G01N33/573;G01N33/574;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
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主权项 |
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地址 |
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