发明名称 |
METHOD FOR HIGH THROUGH PUT SCREENING USING A SMALL SCALE MILL OR MICROFLUIDICS |
摘要 |
The present invention is directed to a high throughput screening (HTS) method, comprising reducing the particle size of a poorly soluble candidate compound to about 1 micron or less using a small scale mill or microfluidics. The product produced from this process is a dispersion of a nanoparticulate candidate compound having one or more surface stabilizers adsorbed onto the surface of teh compound. The reduction in particle size results in an increase in the solubility and/or dispersibility of the compound, thus increasing the effectiveness of HTS conducted in conjunction with the particle size reduction process. The particle size reduction process can be conducted before HTS to make screening compounds soluble and/or dispersible, or after HTS to validate an insoluble or poorly compound determined to be active after screening. |
申请公布号 |
WO03000228(A3) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2002US16589 |
申请日期 |
2002.06.24 |
申请人 |
LINDNER, MARIE;MERISKO-LIVERSIDGE, ELAINE;GOTTARDY, GRETA |
发明人 |
LINDNER, MARIE;MERISKO-LIVERSIDGE, ELAINE;GOTTARDY, GRETA |
分类号 |
G01N33/50;A61K9/10;A61K9/14;A61K31/192;B02C17/02;C12Q1/00;C12Q1/02;G01N33/15;G01N33/53;G01N33/543;G01N37/00 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|