发明名称 |
Preparation and use of a stable formulation of allosteric effector compounds |
摘要 |
A pharmaceutical composition of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salts suitable for parenteral administration includes an aqueous formulation of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salt and a buffer to maintain the pH from about 6 to about 11. The composition in accordance with the invention reduces the amount of particulate matter that forms in solution after heat sterilization. The invention also includes a process for making a pharmaceutical composition of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salt that has a shelf life in excess of thirty days and is useful in parenteral administration.
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申请公布号 |
US2003232887(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
US20020120848 |
申请日期 |
2002.04.10 |
申请人 |
JOHNSON DOUGLAS GILES;DOTY MARK;KIPP JAMES E. |
发明人 |
JOHNSON DOUGLAS GILES;DOTY MARK;KIPP JAMES E. |
分类号 |
A61K47/04;A61B5/055;A61K31/192;A61K31/195;A61K45/00;A61K47/12;A61K47/18;A61K47/26;A61K47/36;A61K47/42;A61K49/10;A61P3/10;A61P9/00;A61P9/10;A61P17/00;A61P31/04;A61P35/00;A61P37/02;A61P43/00;(IPC1-7):A61K31/195;A61K9/14 |
主分类号 |
A61K47/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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