发明名称 |
REGULATION OF TRANSGENE EXPRESSION FOLLOWING AAV TRANSDUCTION |
摘要 |
The present invention provides for methods regulating gene expression both in vitro and in vivo. Specifically, the present invention provides for methods of using adeno-associated virus for transduction of a target gene in a variety of tissues wherein the expression of the transgene is regulated by administration of a proteasome inhibitor. As an example, a therapeutic gene can be delivered in vivo by an adeno-associated virus to a tissue that is not normally transduced by adeno-associated virus. The host would then be administered a proteasome inhibitor in order to induce expression of the therapeutic gene. Hence, the proteasome inhibitor would be administered only when gene expression is desired.
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申请公布号 |
WO02101012(A9) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2002US18194 |
申请日期 |
2002.06.10 |
申请人 |
CHILDREN'S HOSPITAL RESEARCH FOUNDATION |
发明人 |
HIRSCH, RAPHAEL;JENNINGS, KRISTI, J. |
分类号 |
C12N15/864;(IPC1-7):C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12N15/85;C12N15/87;A01N43/04;A61K31/70 |
主分类号 |
C12N15/864 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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