发明名称 |
METHOD FOR MAPPING AND ELIMINATING T-CELL EPITOPES |
摘要 |
The invention provides screening methods for the identification of determinants and epitopes on protein molecules able to evoke an immune response. In particular the invention is concerned with the identification o f epitopes for T-cells in therapeutic proteins. Finally, the invention relates to a combined approach of using epitope mapping in concert with the identification of MHC class II ligands deriving from said epitope mapping method and design of sequence analogous having a reduced number of such ligands and epitopes, respectively.
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申请公布号 |
CA2489180(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
CA20032489180 |
申请日期 |
2003.06.11 |
申请人 |
MERCK PATENT GMBH |
发明人 |
CARR, FRANCIS J.;CARTER, GRAHAM;BAKER, MATTHEW |
分类号 |
C12Q1/02;C07K16/18;C12P21/08;G01N33/50;G01N33/68;(IPC1-7):G01N33/50 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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