| 摘要 |
Disclosed herein are trifluoromethylepinephrine compounds having the followi ng structural formula (I) wherein R1-R5 are each independently selected from th e group consisting of H, alkyl, alkoxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, acyl, thioacyl, sulfonyl mercapto, alkylthio, carboxy, amino, alkylamino dialkylamino, carbamoyl, arylthio, and heteroarylthio; wherein X, Y, and Z are each independently selected from the group consistin g of H or trifluoromethyl with the proviso that at least one of which is trifluoromethyl. Also disclosed are pharmaceutical compositions comprising t he trifluoromethylepinephrine compounds and methods of making and using thereof . Novel trifluoroepinephrine intermediates are also disclosed.
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