发明名称 |
IMMUNOGENIC COMPOSITIONS |
摘要 |
The present invention relates fusion partners which act as immunological fusion partners, as expression enhancers, and preferably to fusion partners having both functions. In particular the fusion partners contain a so-called choline binding domain, for example fusions comprising LytA from Streptococc us pneumoniae, or the pneumococcal phage CP1 lysozyme (CPL1) wherein the cholin e binding domain is modified to include a heterologous T-helper epitope, and a re fused to antigens, particularly poorly immunogenic antigens such as self- antigens, eg tumour specific or tissue specific antigens. The invention also relates to fusion proteins containing them, to their manufacture, to their u se in immunogenic compositions and vaccines and to their use in medicines.</SDO AB>
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申请公布号 |
CA2487831(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
CA20032487831 |
申请日期 |
2003.06.06 |
申请人 |
GLAXO GROUP LIMITED;GLAXOSMITHKLINE BIOLOGICALS S.A. |
发明人 |
VINALS Y DE BASSOLS, CARLOTA;PALMANTIER, REMI M.;CABEZON SILVA, TERESA ELISA VIRGINIA;ELLIS, JONATHAN H.;HAMBLIN, PAUL A.;GERARD, CATHERINE MARIE GHISLAINE |
分类号 |
C07K14/315;A61K38/16;A61K39/00;A61K39/385;A61K39/39;C07K14/33;C12N5/10;C12N15/62;C12N15/63;(IPC1-7):C12N15/62;C07K19/00;A61P35/00;C12N15/31;C12N15/55;C12N9/80 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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