| 摘要 |
<p>(I) (II) (IV) In the above formula, m and n are the same or different and each represents an integer of 1 to 3, provided that m+n is not more than 4; R1 represents -NR4R5 (wherein R4 and R5 are the same or different and each represents hydrogen, optionally substituted lower alkyl, optionally substituted aralkyl, etc.); R2 represents a group of the above formula (II), the above formula (IV), etc.; A represents a single bond, -C(=O)-, -SO2-, -OC(=O)-, etc.; and R3 represents optionally substituted lower alkyl, optionally substituted lower cycloalkyl, optionally substituted aralkyl, etc. It is intended to provide bicyclic pyrimidine derivatives represented by the above general formula (I), quaternary ammonium salts thereof, pharmacologically acceptable salts of the same and the like which have an antiinflammatory effect and an effect of controlling the function(s) of TARC and/or MDC and, therefore, are usable in treating and/or preventing various diseases in which T cells participate, for example, allergic diseases, autoimmune diseases, rejection at transplantation, etc.</p> |
