IMPROVED ISOPRENOID PRODUCTION

摘要

Isolated polynucleotides encoding polypeptides having the activity of enzymes in the mevalonate pathway, e.g. hydroxymethylglutaryl-CoA reductase, isopetenyl diphosphate isomerase, hydroxymethylglutaryl-CoA synthase, mevolante kinase, phosphomevalonate kinase, or diphosphomevalonate decarboxylase; are provided, useful for recombinantly producing isoprenoid compounds such as carotenoids like phytoene, lycopene, beta -carotene, zeaxanthin, canthaxanthin, astaxanthin, adonixanthin, cryptoxanthin, echinenone and adonirubin. Expression vectors, cultured cells, and methods of making isoprenoid compounds are also provided.