发明名称 |
PREPARATION OF PHARMACEUTICAL SALTS OF 4 ( (Z) - (4-BROMOPHENYL) (ETHOXYIMINO) METHYL )-1'-( (2,4-DIMETHYL-1-OXIDO-3-PYRIDINYL) CARBONYL) -4'-METHYL-1,4' BIPIPERIDINE AS CCR5-ANTAGONISTS FOR THE TREATMENT OF AIDS AND RELATED HIV INFECTIONS |
摘要 |
A process for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I) wherein said mixture comprises one or more rotamers or rotamer pairs of the salt in a higher molar percent than other corresponding rotamers or rotamer pairs of the salt, said process comprising reacting said basic compound with an acid in admixture with a solvent. |
申请公布号 |
WO03066593(A3) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2002US37708 |
申请日期 |
2002.11.26 |
申请人 |
SCHERING CORPORATION |
发明人 |
CHEN, MINZHANG;D'SA, BOSCO;LEONG, WILLIAM, W.;TANG, SUHAN |
分类号 |
A61K31/444;A61K31/4545;A61P11/06;A61P19/02;A61P19/06;A61P29/00;A61P31/18;A61P37/08;A61P43/00;C07D401/14 |
主分类号 |
A61K31/444 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|