发明名称 |
HIGHLY AQUEOUS LIQUID CARRIER FORMULATIONS |
摘要 |
Disclosed is a liquid carrier vehicle for a dissolved or suspended pharmaceutically active agent administered to a patient via inhalation of an aerosol where the aerosol is produced by an electrohydrodynamic spraying device and where the liquid carrier vehicle comprises: a. from about 50% V/V to about 100% V/V water; b. from about 0% to about 40% V/V ethanol; c. from about 0% to about 30% V/V of a co-solvent; d. from about 0.5% to about 10% V/V of a pharmaceutically acceptable excipient; and e. from about 0.05% W/V to about 10% W/V of a derivatized carbohydrate surfactant; wherein said liquid carrier has a resistivity of from about 25ohm m to about 8000 ohm m and a surface tension of from about 20 dyne/cm to about 40 dyne/cm. Also disclosed are liquid compositions comprising the liquid carrier vehicle containing a dissolved or suspended pharmaceutically active agent as well as a method of treating a patient using such liquid compositions. |
申请公布号 |
WO03082242(A3) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2003US08157 |
申请日期 |
2003.03.17 |
申请人 |
BATTELLEPHARMA, INC. |
发明人 |
COWAN, SIU, MAN, L.;PALMER, DONNA, T. |
分类号 |
A61K9/00;A61K47/26 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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