PHARMACEUTICAL COMPOSITIONS OF DRUG-OLIGOMER CONJUGATES AND METHODS OF TREATING DISEASES THEREWITH
摘要
Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating diseases in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
申请公布号
WO03022210(A3)
申请公布日期
2003.12.18
申请号
WO2002US28536
申请日期
2002.09.06
申请人
NOBEX CORPORATION;SOLTERO, RICHARD;EKWURIBE, NNOCHIRI, N.;OPAWALE, FOYEKE;REHLAENDER, BRUCE;HICKEY, ANTHONY;BOVET, LI, LI
发明人
SOLTERO, RICHARD;EKWURIBE, NNOCHIRI, N.;OPAWALE, FOYEKE;REHLAENDER, BRUCE;HICKEY, ANTHONY;BOVET, LI, LI