| 摘要 |
<p>A process for easily producing, from an easily available inexpensive starting material, an optically active ß-amino alcohol useful as an intermediate for medicines. An easily available α-substituted ketone is reacted with an optically active amine to produce a mixture of diastereomers of an optically active α-substituted aminoketone. One of the diastereomers is separated optionally after the diastereomers are converted to a salt with an acid. The optically active α-substituted aminoketone or salt thereof thus isolated is subjected to stereoselective reduction to produce an optically active ß-substituted amino alcohol, which is then subjected to hydrogenolysis. Thus, an optically active ß-amino alcohol or a salt thereof is produced.</p> |
