发明名称 |
Non-covalent inhibitors of AmpC beta-lactamase |
摘要 |
beta-lactamases are the most widespread resistance mechanism to beta-lactam antibiotics, such as penicillins and cephalosporins. In response to these enzymes, inhibitors have been introduced. Unfortunately, these inhibitors are also beta-lactams, and resistance to them has developed rapidly. Consequently, the present invention provides a novel structure-based approach to inhibitors of these enzymes.
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申请公布号 |
US2003232830(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
US20030368790 |
申请日期 |
2003.02.19 |
申请人 |
SHOICHET BRIAN K.;POWERS RACHEL A. |
发明人 |
SHOICHET BRIAN K.;POWERS RACHEL A. |
分类号 |
A61K31/18;A61K31/44;A61K31/4965;A61P31/04;C07C311/21;C07D277/74;C07D333/34;C07D333/38;C07D333/40;C07D409/12;(IPC1-7):A61K31/655;A61K31/501;A61K31/519;A61K31/53;A61K31/505;A61K31/443;A61K31/402;A61K31/404 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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