PYRAZOLE-DERIVATIVES AS P38 KINASE INHIBITORS

摘要

This invention is directed generally to pyrazoles that, inter alia, inhibit p38 kinase, TNF, and/or cyclooxygenase-2 activity. Such pyrazoles include compounds generally corresponding in structure to the following formula (I), wherein L1, L2,Xl, X2, X3, X4, X5, X6, Rl, R3A, R3b,R3C, R4, and R5 are as defined in this specification. The pyrazoles further include tautomers of su ch compounds, as well as salts of such compounds and tautomers. This invention also is directed to compositions of such pyrazoles, intermediates for the syntheses of such pyrazoles, methods for making such pyrazoles, and methods for treating (including preventing) conditions (particularly pathological conditions) associated with p38 kinase, TNF, and/or cyclooxygenase-2 activit y.