COMBINATIONS OF ANTI-TISSUE FACTOR ANTIBODIES AND ANTICOAGULANT AND/OR ANTIPLATELET AGENTS

摘要

The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to bind to an epitope comprising the C-terminal macromolecular substrate binding region of TF. The invention also concerns methods of treating TF-VIIa related diseases or disorders comprising administering anti - TF antibodies alone or in combination with at least one additional anticoagulant and/or anti-platelet agent.