11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FORTHE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA

摘要

Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11.beta.-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and othe r symptoms associated with NIDDM.