Physiologically active polyethylene glycol ? interferon alpha conjugate, process for its preparation and pharmaceutical preparation in which it is comprised

摘要

In the present invention, there is disclosed a physiologically active polyethylene glycol ? interferon {alpha} conjugate of the general formula I, in which IFN-{alpha} represents interferon alpha, R and R' represent independently on each other an alkyl group containing 1 to 6 carbon atoms, X denotes the group NH or an oxygen atom, n and n' are integers the sum of which ranges within 600 to 1500 and average molecular weight of the polyethylene glycol unit in the conjugate ranges within 26 000 to 66 000. The invented conjugate is a pharmaceutically active protein exhibiting antiviral and antiproliferative activity and is therefore suitable for the preparation of pharmaceutical compositions. Claimed is also process for its preparation.