摘要 |
<p>Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R<SUP>4</SUP>-R<SUP>7 </SUP>and R<SUP>13 </SUP>are H or alkyl; R<SUP>1 </SUP>is H, alkyl, fluoroalkyl, R<SUP>9</SUP>-arylalkyl, R<SUP>9</SUP>-heteroarylalkyl, alkyl-SO<SUB>2</SUB>-, cycloalkyl-SO<SUB>2</SUB>-, fluoroalkyl-SO<SUB>2</SUB>-, R<SUP>9</SUP>-aryl-SO<SUB>2</SUB>-, R<SUP>9</SUP>-heteroaryl-SO<SUB>2</SUB>-, N(R<SUP>22</SUP>)(R<SUP>23</SUP>)-SO<SUB>2</SUB>-, alkyl-C(O)-, cycloalkyl-C(O)-, fluoroalkyl-C(O)-, R<SUP>9</SUP>-aryl-C(O)-, NH-alkyl-C(O)- or R<SUP>9</SUP>-aryl-NH-C(O)-; R<SUP>2 </SUP>is H and R<SUP>3 </SUP>is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R<SUP>9</SUP>-aryl, R<SUP>9</SUP>-arylalkyl, R<SUP>9</SUP>-heteroaryl, or R<SUP>9</SUP>-heteroarylalkyl, and when X and Z are each CH, R<SUP>3 </SUP>is alkoxy, R<SUP>9</SUP>-aryloxy, R<SUP>9</SUP>-heteroaryloxy, alkylC(O)O-, alkylaminoC(O)O-, alkylC(O)NR<SUP>13</SUP>-, alkylOC(O)NR<SUP>13</SUP>- or alkylaminoC(O)NR<SUP>13</SUP>-; or R<SUP>2 </SUP>and R<SUP>3 </SUP>together are -O, -NOR<SUP>10</SUP>, -N-NR<SUP>11</SUP>R<SUP>12 </SUP>or -CH-alkyl; R<SUP>8 </SUP>is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R<SUP>9</SUP>-R<SUP>12 </SUP>are as defined; are disclosed for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis, as well as pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents.</p> |