A DERIVATIVE OF 3,7-DIAZABICYCLO [3,3,1] COMPOUNDS , PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A METHOD FOR PRODUCING AND COMPOSITION BASED THEREON AS ANTIARRHYTHMIC AGENTS

摘要

There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-di-azabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tret-butyl 2-(7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl)ethylcarbamate; tret-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tret-butyl 2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arrhythmias.