| 摘要 |
<p>PCT No. PCT/JP97/03215 Sec. 371 Date Mar. 12, 1999 Sec. 102(e) Date Mar. 12, 1999 PCT Filed Sep. 12, 1997 PCT Pub. No. WO98/11089 PCT Pub. Date Mar. 19, 1998A compound of the formula in which R1 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy)lower)alkyl, carboxy)lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, R2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, R3 is hydrogen or amidino-protective group, A is lower alkylene or carbonyl, X is Y is -S- or -SO2-, Z is -S- or -O-, or pharmaceutically acceptable salts thereof which is useful as a medicament.</p> |
