发明名称 |
SNARES AND METHODS OF CONTROLLING CYTOKINESIS |
摘要 |
Two members of the SNARE membrane fusion machinery, syntaxin 2 and endobrevin/VAMP-8, have been found to be important to cytokinesis in mammalian cells. Inhibition of syntaxin 2 and endobrevin/VAMP-8 function by over-expression of non-membrane anchored mutants of these proteins causes failure of cytokinesis leading to the formation of binucleated cells. Time-lapse microscopy shows that only midbody abscission is prevented by over-expression of these non-membrane anchored mutants, and that other cellular events preceeding midbody abscission, such as furrowing, are unaffected. |
申请公布号 |
WO03066098(A3) |
申请公布日期 |
2003.12.11 |
申请号 |
WO2003US04006 |
申请日期 |
2003.02.10 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION;WEIMBS, THOMAS;LOW, SENG, HUI |
发明人 |
WEIMBS, THOMAS;LOW, SENG, HUI |
分类号 |
A61K38/00;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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