发明名称 |
Retarded release pharmaceutical composition, obtained without use of organic solvents or water by densifying mixture of active agent and retarding polymer in heated rollers |
摘要 |
Production of a retarded release pharmaceutical composition (A) involves: (a) forming a mixture of active agent (I) and release retarding polymer (II); (b) densifying the mixture by passage between two rollers at a temperature of more than 40 [deg]C under a force of 15-40 kN per cm of roller width; (c) comminuting the densified mixture to the required particle size; and (d) optionally further processing the mixture. An independent claim is included for the composition (A) obtained by the process.
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申请公布号 |
DE10224170(A1) |
申请公布日期 |
2003.12.11 |
申请号 |
DE20021024170 |
申请日期 |
2002.05.31 |
申请人 |
DESITIN ARZNEIMITTEL GMBH |
发明人 |
FRANKE, HANSHERMANN;LENNARTZ, PETER;RAIMER, JOERN |
分类号 |
A61K47/30;A61K9/14;A61K9/16;A61K9/20;A61K9/22;A61K9/26;A61K9/48;A61K31/19;A61K31/4015;A61K31/53;A61K31/54;A61K31/55;A61K45/00;A61K47/32;(IPC1-7):A61K9/22 |
主分类号 |
A61K47/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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