The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in liver tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by liver toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
申请公布号
WO03064624(A3)
申请公布日期
2003.12.11
申请号
WO2003US03194
申请日期
2003.01.31
申请人
GENE LOGIC, INC.;MENDRICK, DONNA;PORTER, MARK;JOHNSON, KORY;HIGGS, BRANDON;CASTLE, ARTHUR;ELASHOFF, MICHAEL
发明人
MENDRICK, DONNA;PORTER, MARK;JOHNSON, KORY;HIGGS, BRANDON;CASTLE, ARTHUR;ELASHOFF, MICHAEL
