发明名称 |
RATIONALLY DESIGNED POLYSACCHARIDE LYASES DERIVED FROM CHONDROITINASE B |
摘要 |
The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solutio n. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.
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申请公布号 |
CA2493509(A1) |
申请公布日期 |
2003.12.11 |
申请号 |
CA20032493509 |
申请日期 |
2003.06.03 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
POJASEK, KEVIN;SASISEKHARAN, RAM;RAMAN, RAHUL |
分类号 |
A61K38/00;C12N9/88;C12N15/60;(IPC1-7):C12N9/88;A61K38/51 |
主分类号 |
A61K38/00 |
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