发明名称 CFTR MODIFIER GENES AND EXPRESSED POLYPEPTIDES USEFUL IN TREATING CYSTIC FIBROSIS
摘要 The discovery that CFTR modifier genes, in particular the Kir4.2 gene, the expressed polypeptide(s), as well as genetic and polypeptide regulators thereof, can be used to treat cystic fibrosis (CF), or at least the conditio ns that cause CF. Methods and products for detecting and/or identifying CFTR modifier genes, their respective expressed polypeptides, the genetic regulators of such CFTR modifier genes, and the regulators of their respecti ve expressed polypeptides are disclosed. Also disclosed are compositions and methods using these CFTR modifier genes, their respective expressed polypeptides, genetic regulators of these CFTR modifier genes, and/or CFTR modifier polypeptide regulators for the purpose of treating CF, or at least the conditions that cause CF, are disclosed.
申请公布号 CA2488012(A1) 申请公布日期 2003.12.11
申请号 CA20032488012 申请日期 2003.05.30
申请人 CHILDREN'S HOSPITAL MEDICAL CENTER 发明人 WHITSETT, JEFFREY ALLEN;ARONOW, BRUCE JEFFERSON;CLARK, JEAN CANTWELL
分类号 G01N33/53;A61K31/352;A61K31/522;A61K38/00;A61K45/00;A61K48/00;A61P11/00;A61P11/12;A61P29/00;A61P43/00;C07D311/92;C07D473/06;C07K14/47;C12M1/00;C12N15/09;C12Q1/02;C12Q1/26;C12Q1/44;C12Q1/68;G01N37/00;(IPC1-7):C12Q1/68;A61K31/00;A61P37/00;A61K38/17;G01N33/50 主分类号 G01N33/53
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