摘要 |
There is provided pharmaceutically-acceptable acid addition salts of compounds of formula (I), wherein R<1> represents C1-2 alkyl substituted by one or more fluoro substituents; R<2> represents C1-2 alkyl; and n represents 0, 1 or 2, which salts are useful as prodrugs of competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
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申请人 |
ASTRAZENECA AB;AHLQVIST, MATTI;BOHLIN, MARTIN;INGHARDT, TORD;LUNDBLAD, ANITA;SIGFRIDSSON, CARL-GUSTAF |
发明人 |
AHLQVIST, MATTI;BOHLIN, MARTIN;INGHARDT, TORD;LUNDBLAD, ANITA;SIGFRIDSSON, CARL-GUSTAF |