| 摘要 |
<p>It has been found that aggregation of ligand-specific antibodies enhances their ablility to interact with liposomes in order to form ligand-specific immunoliposomes. The invention provides a process for the manufacture of immunoliposomes for targeting to a ligand of interest, comprising the step of : (a) treating a solution comprising antibody specific for ligand of interest, to give aggregated antibody; and (b) mixing the aggregated antibody with liposomes, thereby forming immunoliposomes. The process avoids the need for chemical modification of antibody and/or liposomes necessary for conjugation, it is rapid and it is simple.</p> |
