AMID protein, nucleic acid molecules, and uses thereof

摘要

Described here is the cloning and characterization of a novel AIF homologous molecule designated AMID, which is co-localized with mitochondria, and which induces cell death with characteristic apoptotic morphology, independent of caspase activation and p53. Bcl2. Disclosed herein are AMID proteins, fragments and homologues, as well as nucleic acid molecules encoding such proteins, and methods of making and using the same.