发明名称 |
SUICIDE TETRAMERS COMPRISING MHC CLASS I AND USES THEREOF |
摘要 |
The present invention provides a cytotoxic MHC I conjugate comprising a cytotoxic moiety, biotinylated MHC I monomers which each comprise an antigenic peptide and streptavidin, bound to the cytotoxic moiety or to a biotinylated cytotoxic moiety and to the biotinylated MHC I monomers. Alternative constructs comprising a cytotoxic moiety and biotinylated MHC I monomers where each monomer comprises an antibody fragment also are provided. The cytotoxic moiety may comprise an 225Ac radionuclide or other cytotoxin. Further provided are methods of killing CD8<+> T cell clonal populations. |
申请公布号 |
WO03101473(A1) |
申请公布日期 |
2003.12.11 |
申请号 |
WO2003US16934 |
申请日期 |
2003.05.30 |
申请人 |
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
SCHEINBERG, DAVID;MCDEVITT, MICHAEL;YUAN, RUI-RONG |
分类号 |
A61K38/00;A61K38/17;A61K47/48;A61K51/04;A61K51/08;C07K14/74;C12N5/00;C12N5/06;C12N5/08;(IPC1-7):A61K38/00;A61K39/44;A61K39/395;A61K51/00;C07K1/00;C07K14/00;C07K19/00;G01N33/53;G01N33/567 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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