ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS

摘要

The invention relates to anti-thrombotic compounds of general formula (I), where R1 to R4, Ar, A, m and n are as defined in claim 1, the tautomers, stereoisomers, mixtures, pro-drugs and salts thereof which have worthwhile properties. Compounds of the above general formula (I), in which Ar = a phenyl or naphthyl group substituted with the groups R5, R6 and R7 and R5 = a CN group, represent worthwhile intermediate products in the synthesis of the corresponding compounds of general formula (I), in which R5 = an amidino group substituted with one or two C1-3 alkyl groups. The compounds of the above general formula (I), with the exception of those compounds in which Ar = a phenyl or naphthyl group substituted with the groups R5, R6 and R7 and R5 = a CN group, have worthwhile pharmacological properties, in particular an anti-thrombotic effect and a factor Xa-inhibiting effect.