| 摘要 |
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel derivatives of thiazole of the formula (I) wherein R1 means group of formulas: (a) , (b) , (c) and (d) wherein R2 means group of the formula (II) ; R3 means hydrogen atom, alkyl, cycloalkyl and so on; R4 means alkyl, phenyl, heteroaryl; R5 and R6 each independently each of other means hydrogen atom, heteroaryl; R7 and R8 each independently each of other means hydrogen atom; or R7 and R8 in common with nitrogen atoms with which they are bound form 5-6-membered heterocycle; R9 means hydrogen atom, alkyl, cycloalkyl; R10 means phenyl, benzyl and so on; A means carbonyl or sulfonyl; B means hydrogen atom; each among a-m means 0 or positive number from 0 to 2 but not 0 when R1 means -NH2; b means number from 0 to 4; c, d, f, g, k, l and m each independently each of other means 0 or 1 and therefore each among c, f and g can't mean simultaneously 0 and owing to m doesn't mean 0 when f or g mean 1; i means 0; e means number from 0 to 3; h means number from 0 to 5; j means number from 0 to 2 and sum e, h and j = 2-7; and their pharmaceutically acceptable salts. Invention relates also to derivatives of thiazole of the formula (XXXI) wherein and a have values indicated above and wherein R3 doesn't mean hydrogen atom or methyl when R1 means group (e) , (f) . Invention relates also to method for preparing compound of the formula (I) by interaction of compound of the formula (XXXI) with amine of the formula (III) given in description of invention. Invention relates also to pharmaceutical composition eliciting properties to inhibit binding adhesive proteins and containing compound of the formula (I) and therapeutically inert carrier. Invention provides preparing the new compound eliciting properties to inhibit binding adhesive protein. EFFECT: improved preparing method, valuable medicinal properties of compounds. 20 cl, 1 tbl, 176 ex
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